- Pharmacokinetic Properties
- Adverse Reaction
exacerbation of chronic obstructive pulmonary disease, pneumoniaSkin and soft tissue infections, Lyme disease, Eradication of helicobacter pylori
Annythromycin is easily inactivated by gastric acid; therefore, orally administered formulations are given as either enteric-coated or more stable salt or esters. it is metabolized by demethylation in the liver by hepatic enzyme CYP3A4. Its main elimination route is in the bile with renal excretions.
Annythromycin is contraindicated in patients with known hypersensitivity to this antibiotic. it should be avoided by patients taking terfenadine, astemizole, cisapride or pimozide.
Diarrhea, nausea, abdominal pain and vomiting. It can also cause headaches, insomnia, abnormal liver function tests. Allergic reactions include rashes and anaphylaxis, jaundice, hepatitis .
There is possible interaction between annyclarit with drugs for heart diseases(digoxin, disopyramide), allergies(terfenadine, astemizole), asthma(theophyline), epilepsy(carbamazepine) or HIV(ritovir)
Adults: 250-500mg to be taken 3-4 times daily Prophylaxis for Streptococci: 250mg (to be taken twice daily)