AG-FLUTAMIDE

  • Indication
  • Pharmacokinetic Properties
  • Adverse Reaction
  • Dosage
Benign prostate hyperplasia Hirsutism in women Polycystic ovary syndrome(PCOS)Juvenile nasopharyngeal angiofibroma
After absorption, AG-flutamide is quickly alpha-hydoxylated to its primary active form, hydoxyflutamide. It is excreted in various forms in the urine, the primary form being 2-amino-5-nitro-4-(trifluoromethyl)phenol. It is excreted primarily in the urine with 4.2% excreted in faeces. AG-Flutamide has a fairly short duration and as a result must be administered three times daily(every 8 hours) 
Gynaecomastia(sometimes with galactorrhoea), nausea and vomiting, diarrhea, increased appetite, decreased libido, hepatocellular necrosis, insomnia, cholestatic jaundice
Prostate cancer 750mg daily(in 3 divided doses) Polycystic ovary syndrome 500mg daily Idiopathic hirsutism 125mg daily
  • Date
  • Categories